The Heart Health Genetic Test is the firstand only IL1 gene test to identify an individuals predisposition forover-expression of inflammation and increased risk for CVD and acute cardiacevents. The Genetics of Inflammation.
The General Nutrition Genetic Test identifies nutrient metabolism (including vitamin B and antioxidants). Here’s what it tells us.
General Nutrition Health Genetic Test Explanation
| Tested Genes | Increased risks if it is positive | Supplements recommended |
| MTHFRTCN2 | Folate deficiency related to birth defects, cardiovascular disease and certain cancers. B12 deficiency related to mood swings, depression and poor memory, ADD, severe anemia in early infancy, and cardiovascular disease. | Folic acid and additional B Complex vitamins. Ocean Essentials Heart Health or 600 Omega 3.
B12(in form of Methylcobalamine), Sublingual B12 or B12 injection if you have digestive problems. O. E. Omega 3 (Positive on either genes indicates a need for Bromelain in Nutrilite Digestive Enzymes, especially if you are over 40) |
| SOD2 | Breast, ovarian, or prostate cancer. | Nutrilite Concentrated Fruits and Vegetables, vitamin C, E, A, multi-carotene, Selenium, and Saw Palmetto (for male) |
| GSTM1 | Lung cancer, bladder cancer. About ½ of the population is positive, which means they lack the ability to handle pollutants and toxins in air and water. | Nutrilite Antioxidant Complex in US, Mekiwin Horseradish in Canada . An Atmosphere to filter air and an eSpring to purify water keeps toxins from building up in the lungs or bladder. |
| PON1 | High tendency to have LDL oxidation, which leads to coronary heart disease, & strokes. | Nutrilite Concentrated Fruits and Vegetables, O. E. Omega 3 |
| XRCC1 | Lack of DNA repairing ability, which leads to skin cancer and gastric cancer. | Multi-carotene (For diabetics, take A + Zinc instead), Nutrilite Fruit & Vegetable Concentrate, and other antioxidants. |
Suggestions: Nutrilite Double X is the foundation with B vitamins and broad antioxidant protection. Nutrilite Daily would be a 2nd choice with lowercost. The specific nutrients above in addition to either. Add what you can afford from the doctors’ suggestions above.
MTHFR (Methylenetetrahydrofolate reductase) is a key enzyme in folate metabolism. Folate deficiency is implicated in cancer development. It has been recognized that some people have a common MTHFR gene variant that impairs their ability to process folate. This defective gene leads to elevated levels of homocysteine in some people who inherit MTHFR variants from both parents. Elevated homocysteine levels may cause irritation of the blood vessels,thus shows an increased risk for (1) hardening of the arteries(atherosclerosis), which could eventually result in a heart attack and/or stroke, and (2) blood clots in the veins, referred to as venous thrombosis.
TCN2 (Transcobalamin II), a plasma globulin, is the primary transport protein for vitamin B12. Genetic absence of TNC2 leads to severe megaloblastic anemia in early infancy. Vitamin B12 (cobalamin) deficiency also has been implicated in a spectrum of neuropsychiatric disorders. Because homocysteine metabolism requires both folate and vitamin B12 as cofactors, B12 deficiency can result in elevated plasma homocysteine levels.
SOD2 (superoxide dismutase 2), also called as MNSOD, Mn-SOD. Superoxidedismutase is a major enzyme that is responsible for the detoxification of reactive oxygen species in the mitochondria. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancers such as breast cancer, ovarian cancer, and prostate cancer.
GSTM 1 encodes for enzymeglutathione S-transferase M1. GSTM1 gene may modulate the internal dose of environmental carcinogens and thereby affect the risk of developing bladder cancer. Approximately 50% of all humans inherit two deleted copies of the GSTM1 gene. Half of the non-smokers who do not have the GSTM1 gene have a statistically significant greater risk of lung cancer from exposure to environmental tobacco than the other half.
PON1 encodes for paraoxonase, an enzyme that helps HDL (good) cholesterol prevent the oxidation of LDL (bad) cholesterol. LDL oxidation promotes heart and blood vessel disease. “Paraoxonase has antioxidant effects and protects against atherosclerosis. Higher levels of PON1 mean more protection against the risk of stroke or vascular disease in general, including heart attacks.Paraoxonase levels don’t correlate directly with the amount of HDL a person has, but the enzyme does appear to play a role in HDL function.” Genetic abnormality may increase stroke risk fourfold among young people.
XRCC1 (X-ray repair cross-complementing group 1) is a DNA repair gene. Genes involved in DNA repair and maintenance of genome integrity are critically involved in protecting against mutations that lead to cancer and/or inherited genetic disease have an important role in protecting individuals from cancer-causing agents. Studies show that XRCC1 variants may contribute to the risk of developing certain cancers such as gastric cancer and skin cancer.